Health Testing Reviews for 23andMe

£104.00 £149.00

At a Glance

Editor's Rating:
5 out of 5 stars
Customer Service:
5 out of 5 stars
Clarity of Results:
5 out of 5 stars
References Cited:
5 out of 5 stars
Value for Money:
4.5 out of 5 stars

Summary

All in all, the health report produced by 23andMe’s DNA test was very impressive. What really stood out for me was the responsible and comprehensive manner in which they explained each finding, and outlined the limitations of the analyses.

I was pleased to see that all of the reports had been based on established research, and was impressed that the carrier status and genetic risk reports were FDA approved, something I haven’t seen in any other tests. This allowed me to fully trust the findings and made them feel genuinely meaningful.

Access to the 23andMe community was provided in every section of the account, where ‘forum style’ questions had been asked and answered – I found this really beneficial. It was also extremely powerful to see that the scientific research behind each of the 73 results was cited, with links to the original studies.

To conclude, the 23andMe test is great value for money and I would highly recommend it.

Full Review

23andMe reports on your genetic predisposition to various diseases, carrier status and inherited conditions. It also reports on genetic traits, genetic ancestry, and helps you find living relatives.

Please note that reviews for the ancestry-related aspects of the test can be found here.

Product Expectations

23andMe’s website advised that by knowing more about my DNA, I could take steps towards living a healthier life. The test would help me discover if I carry genetic variants that could affect my children, and identify genetic risk factors which could help me make better lifestyle choices (I wasn’t sure what a ‘genetic risk factor’ was at this point). I also learned that I’d receive genetic information relating to my ‘Wellness’ which would include details ranging from my response to caffeine to how deeply I sleep, as well as a list of the physical traits that I’ve inherited such as hair colour.

The full list of 70+ health conditions and traits to be reported on was provided, with links to detailed explanations about the scientific criteria for reporting genetic associations. There was also a ‘How It Works’ page that included a three-minute video in which the whole process of taking the sample, activating the kit and receiving results was explained. I also learned that I would be able to track my order, and that my results would be provided in an online account when they were ready. I found this really helpful and appreciated being able to see what I’d receive before purchasing.

I repeatedly read that 23andMe’s reports were intended for informational purposes only, and that they don’t diagnose disease or illness.

Ordering Experience

I received the kit three working days after ordering and used the spit collection tube to provide a sample – the process was effortless. Instructions inside the kit advised that I consult with a genetic counsellor if I had any questions interpreting my results, but I wasn’t sure how I’d go about this.

A list of limitations was provided for each section of the report that I'd receive, and the instructions went on to warn me that 23andMe’s test is not a substitute for a healthcare professional, and that the results should not be used to diagnose any condition. It was good to see that the term ‘genetic risk factor’ was clearly explained in this document.

The return address had been printed on the underside of the box and the return postage had already been paid, so all I had to do was pop it in the post. I received confirmation by email that my sample reached the lab two weeks later.

Online Registration

Friendly warnings on the kit advised that I must register online before dispatching my sample back to 23andMe. During this process, I went through the privacy policy and noticed that even if I didn’t consent to 23andMe’s research program, my genetic and self-reported information would still be shared with other companies. I was interested to read that it would be shared as aggregated information that couldn’t be linked back to me.

The process also required me to agree to terms and conditions, and after going through them, I read that if my genetic or self-reported information helped 23andMe (or its partners) develop any research or commercial products, I’d have no right to these developments, and would not receive any compensation. I wondered what my genetic information was really worth to 23andMe…

The Results

Four weeks after the lab acknowledged receipt of my sample, I received an email to say that my results were ready – earlier than I was expecting! I was directed to log in to the online account that I’d set up when I’d registered.

Upon logging in, the homepage showed a list of the 'Ancestry' and 'Wellness' results, which only made up 13 reports in total (of the 70+ reports advertised on the site).

To access my 'Carrier Status', ‘Genetic Health Risks’ and 'Traits' results I had to take an ethnicity questionnaire. It was explained that this was in order to provide the most accurate health results possible. The questions were straightforward and took less than five minutes to complete.

Once I had taken the ethnicity questionnaire, the number of reports available to view rose dramatically to more than 80. There were links to the five different categories as well as to tools, which included ‘Share and compare’ and ‘Research’ and ‘DNA Relatives’. There were also quick access links to features such as ‘How does DNA work?’ and a research survey question.

Results Section: Carrier Status

When I viewed the Carrier Status section, I was presented with a list of 42 conditions that can be passed on genetically from parents to children. A part of this list is shown below.

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A section of my Carrier Status results.

A section of my Carrier Status results.

I was relieved to see that I hadn’t tested positive for the genetic variants associated with most of the conditions. However, I did have one variant related to Tay-Sachs disease. I had never heard of this, but was informed that my HEXA gene contained a variant that meant I could be a carrier. The symptoms were also described, but I was reassured by the explanation that both my partner and I would have to be carriers to potentially pass on the condition, in which case our child would have a 25% chance of having it (shown below).

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My Tay-Sachs Disease Carrier Status result.

My Tay-Sachs Disease Carrier Status result.

Despite being somewhat reassured by this explanation, I was pleased to see a prominent link to advice about connecting with a genetic counsellor at the bottom of the page. The link included a list of reasons I might want to consider seeing a genetic counsellor, and a range of ways to get in touch with one. There was also an option to print my report, to share with a medical professional or members of my family.

Each Carrier Status result came in two parts: ‘Overview’ and ‘Scientific Details’. The latter of these provided more detailed information about the links between DNA and the disease, including my genotype, the typical vs. the variant sequence, and the percentage of other 23andMe customers that carried this particular variant.

It also provided information about the other markers that had been tested to detect variants associated with the condition, of which there were four for my Tay-Sachs disease result. I wasn’t quite sure about what the difference between a marker and a variant was, but luckily, by clicking on them, I was provided with an explanation about what each meant. It explained that a variant was a difference in the DNA sequence between people and a marker was a place in the sequence that this variant was found.

Results Section: Genetic Health Risks

The next section revealed my risk of developing four different health conditions. It assessed how likely I was to suffer from Late-Onset Alzheimer’s Disease, Parkinson’s Disease, Alpha-1 Antitrypsin Deficiency and Hereditary Thrombophilia, according to my DNA.

Before seeing the results, I was taken through a ‘Genetic Health Risk Tutorial’. A part of it is shown below.

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A part of the Genetic Health Risk Tutorial.

A part of the Genetic Health Risk Tutorial.

This explained various aspects related to these reports specifically. It included information about what variants are and their possible effects, the difference between genetic predisposition and having the disease, and also the factors other than genetics that might be involved in the development of a health condition. This feature made me feel more prepared for the results and better informed about their meaning.

The result I was most interested in was the one that assessed my risk of developing Late-Onset Alzheimer’s Disease, but it was also the one I was most worried about. Having a family history of the disease meant that I initially wasn’t sure if I wanted to know my risk, but after careful consideration had decided I wanted to be prepared if I was more likely to get it. I was pleased to see, therefore, that I didn’t carry the variant that was associated with a higher risk.

I was understandably relieved, but it was also made clear that this didn’t mean I wouldn’t get the disease. As well as stating this fact, the limitations of the test were outlined and the other factors, such as ethnicity and lifestyle were explained in detail. I was surprised but impressed that this was included. This honesty and openness further increased my trust in the results and the service as a whole.

Luckily, I don’t carry any of the variants that indicated a higher risk of the four conditions. All of these results included similar information to the Carrier Status section of the report, including the location and details about the variant(s) and gene(s) analysed, hyperlinked references and even a table of the different risks for different groups of people.

Results Section: Traits

My Traits results outlined some of the genetic factors affecting 22 of my characteristics. These were split into the following categories: ‘Taste and Smell’, ‘Facial Features’, ‘Hair’, ‘Physical Characteristics’, ‘Physical Responses’ and ‘Skin’. Each section had between one and six reports and it was fun to compare my actual experiences with the conclusions drawn from my DNA analysis. The most memorable result was probably the one that suggested I am more likely to be able to smell an asparagus metabolite in my urine than others (shown below)!

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My Asparagus Odor Detection result.

My Asparagus Odor Detection result.

Each result was accompanied by an explanation, as well as a percentage of other 23andMe customers that share that trait. The explanations were interesting yet concise and, similarly to the Carrier Status reports, each result was accompanied by more detailed scientific information about how the conclusion had been reached. It appeared that a lot of the information was, at least in part, based on the self-reported conclusions made in customer surveys, which didn’t seem like a particularly scientific method, and may explain why my eye colour (green/blue) was predicted as brown. It was interesting to be able to compare my results with those of a similar ethnicity, a comparison which was made in each report.

Results section: Wellness

The Wellness section contained seven reports in total, that ranged from results about lactose intolerance to sleep movement. I was surprised to read that rather than testing for my reaction to caffeine, the result relating to this actually indicated that I was less likely to consume caffeine , a behavioural choice that I had previously assumed had little or no genetic influence.

I was slightly sceptical, and wondered this conclusion had been made. This is where the scientific details (shown below) and references were really helpful, as they showed that there were several published research studies specifically backing the idea that certain genetic variants can affect the amount of caffeine someone is likely to consume, not just their reaction to it.

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The scientific details about my Caffeine Consumption result.

The scientific details about my Caffeine Consumption result.

Although I didn’t display any particularly unusual wellness characteristics, this section was interesting. It was made very clear that the information was not intended for medical use, but it would have been good to have slightly more information on how the characteristics might affect me and potentially how to respond practically, especially as they were largely non-medical traits. For example, the results suggested that I am likely to move more than the average person whilst sleeping, and although I was told that this could be disruptive to my sleep, there was no further explanation or tips on how to reduce these potentially disruptive effects.

However, there were other results in this section which did provide helpful advice and information, such as the saturated fat result. I was interested to learn that I’m likely to be the same weight regardless of whether I eat a diet high or low in saturated fat. But this doesn’t mean that I am any less likely to suffer the internally harmful effects, such as heart disease.

It was really useful to have the different types of fat explained, and eye-opening to learn the foods that contained high levels of saturated fat in them (steak and ice cream for example), as well as those high in the healthier, unsaturated fat (nuts, fish, avocados etc.).

Summary

All in all, the health report produced by 23andMe’s DNA test was very impressive. What really stood out for me was the responsible and comprehensive manner in which they explained each finding, and outlined the limitations of the analyses.

I was pleased to see that all of the reports had been based on established research, and was impressed that the carrier status and genetic risk reports were FDA approved, something I haven’t seen in any other tests. This allowed me to fully trust the findings and made them feel genuinely meaningful.

Access to the 23andMe community was provided in every section of the account, where ‘forum style’ questions had been asked and answered – I found this really beneficial. It was also extremely powerful to see that the scientific research behind each of the 73 results was cited, with links to the original studies.

To conclude, the 23andMe test is great value for money and I would highly recommend it.

See a description of this DNA test from 23andMe >